BIOINFORMATICS COURSE LISTING

The Master of Science degree in Bioinformatics consists of 40-41 graduate hours comprised of required courses and electives drawn from a restricted menu. The program of study is intended to be a course-intensive experience requiring two years of full-time academic work, including a summer internship in the public or private sector between the first and second years. The internship is required of all students in the program and it may be counted as a 3 credit hour elective course. Thesis is an option but not a requirement for this degree.

I.   Internship

The student is responsible for securing an internship offer from an academic, industry, or government institution which is a current or potential employer of bioinformatics professionals. For the internship to count towards the Master of Science degree in Bioinformatics, the student must obtain pre-approval from the Bioinformatics Program Committee before the start of the internship. An evaluation form will be sent to the employer at the end of the internship and the student must receive a grade of “Satisfactory” or better in order to fulfill the internship requirement of this degree.

II.  Courses

1.   Required courses and seminars (28 semester hours):

BINF      5341      Analysis and Modeling of Biological Structures

BINF      5351      Introduction to Bioinformatics I: Basic Sequence Comparisons

BINF      5352      Introduction to Bioinformatics II: Gene Finding and Genomic Comparison

BINF      5354      Post-Genomic Analysis

BIOL      5340      Structure and Function of Macromolecules

STAT     5328      Introduction to Statistical Analysis

MIT         5310      Fundamentals of Computers

MIT         5314      Data Base Applications

Plus 4 credit hours of seminars chosen from:

BINF      5110      Biology Seminar for Bioinformatics

BINF      5111      Chemistry Seminar for Bioinformatics

BINF      5112      Computer Science Seminar for Bioinformatics

BINF      5113      Mathematics Seminar for Bioinformatics

2. In addition, students will take a total of 12 or 13 semester hours chosen from the list of courses below, and they should take courses from lists b) and c) only after they have completed 18 semester hours in the program. No more than 6 hours from list b) can be counted towards the M.S. in Bioinformatics degree.

a) Regular courses

BIOL      5316      Biosystematics

BIOL      5326      Advances in Immunological Concepts

BIOL      5329      Physiology of the Bacterial Cell

BIOL      5342      Synthesis and Degradation of Macromolecules

BIOL      5343      Mechanisms of Cellular Toxicity

BIOL      5344      Molecular Pathogenesis

CHEM   5329      Contemporary Topics in Organic Chemistry

CHEM   5339      Contemporary Topics in Biochemistry

CHEM   5342      Physical Biochemistry

CS         5334      Parallel and Concurrent Programming or

MIT         5328      Applied Multiprocessing Computing

(Only one of CS 5334 or MIT 5328 can count as an elective for the M.S. degree in Bioinformatics)

CS         5336      Scientific and Program Visualization

CS         5341      Advanced Computer Architecture

CS         5350      Advanced Algorithms

CS         5351      Interval Computations

CS         5353      Topics in Emerging Computing Paradigms

CS         5383      Topics in Software Assurance

MATH    5330      Computational Methods of Linear Algebra

MATH    5335      Techniques in Optimization

MIT         5316      Web-Based Computing

MIT         5328      Applied Multiprocessing Computing

STAT     5336      Analysis of Categorical Data

STAT     5386      Stochastic Processes

STAT     5388      Multivariate Data Analysis

STAT     5390      Nonparametric Statistics

STAT     5391      Time Series Analysis

STAT     5392      Statistical Computing

All CS and MIT electives require prior approval from the Department of Computer Science before enrollment.

b) Project/Internship courses.

BINF      5353      Bioinformatics Internship

BIOL      5302      Research in the Biological Sciences

CHEM   5396      Graduate Research in Chemistry

CS         5391      Individual Studies

CS         5396/7   Graduate Projects

MATH    5396      Graduate Research

STAT     5396      Graduate Research

c) Thesis courses. Six hours of thesis courses BINF 5398 and BINF 5399 may be taken in place of regular elective course in list a) above to count towards the M.S. in Bioinformatics degree. All University requirements for Master’s theses apply.

d) A maximum of up to six credit hours of approved advanced undergraduate courses in biology, chemistry, computer science, mathematics, or statistics. Only undergraduate courses which are listed as applicable towards graduate degrees by the Graduate School can be counted towards the M.S. in Bioinformatics degree (see Graduate Catalog listings under individual Departments). Approval from the Graduate Advisor is required.

3. With the approval of the Bioinformatics Program Committee and the Graduate School, up to 6 semester hours of graduate work may be transferred from another accredited institution to replace equivalent courses listed in 1 and 2 a) above. Only credit hours that have not been counted towards a previously awarded degree are allowed to be transferred.

 

For Graduate Students Only

 

Bioinformatics (BINF)

 

5110   Biology Seminar for Bioinformatics (1-0)

Reading and discussions of various topics in the biological sciences related to bioinformatics. Each student is expected to give at least one presentation during the course. Prerequisite: Department approval.

 

5111   Chemistry Seminar for Bioinformatics (1-0)

Reading and discussions of various topics in Chemistry related to bioinformatics. Each student is expected to give at least one presentation during the course. Prerequisite: Department approval.

 

5112   Computer Science Seminar for Bioinformatics (1-0)

Reading and discussions of various topics in computer science related to bioinformatics. Each student is expected to give at least one presentation during the course. Prerequisite: Department approval.

 

5113   Mathematics Seminar for Bioinformatics (1-0)

Reading and discussions of various topics in mathematical sciences related to bioinformatics. Each student is expected to give at least one presentation during the course. Prerequisite: Department approval.

 

5341   Analysis and Modeling of Biological Structures (2-3)

Introduction to the principles and methods used for the three-dimensional structural determination and simulation of macromolecules of biological interest. Molecular recognition, conformational analysis, and molecular dynamics; ligand design and docking; and modern methods for protein structure determination. Prerequisite: Department approval. (BINF 5341 is the same course as CHEM 5341.) Laboratory fee required.

 

5351   Introduction to Bioinformatics I: Basic Sequence Comparisons (2-3)

Theory and practice of sequence analysis, with an emphasis on nucleic acid comparisons and homologue determination. Includes understanding and use of Internet and computational tools with both public sequencing databases and experimental data. Prerequisite: Department approval. (BINF 5351 is the same course as BIOL 5351.) Laboratory fee required.

 

5352   Introduction to Bioinformatics II: Gene Finding and Genomic Comparisons (2-3)

A continuation of BINF 5351 with an emphasis on the analysis of protein structural information. Also includes gene annotation and whole genome comparisons. (BINF 5352 is the same course as BIOL 5352.) Prerequisite: Department approval. Laboratory fee required.

 

5353   Internship in Bioinformatics (0-0-6)

Practical on-the-job experience as an intern academic, industry, or government institution which is a current or potential employer of bioinformatics professionals. No more than 3 hours of BINF 5353 may count toward a graduate degree. Prerequisite: Department approval.

 

5354   Post-Genomic Analysis (2-3)

The extraction and confirmation of information from entire and partially assembled genome sequences. Includes the design and use of DNA arrays, SNP’s and applied proteomics in the identification and verification of expressed genes of interest. (BINF 5354 is the same course as BIOL 5354 and STAT 5354.) Prerequisite: Department approval.  Laboratory fee required.

 

5398   Thesis (0-0-3)

Initial work on the thesis. Prerequisite: Department approval.

 

5399   Thesis (0-0-3)

Continuous enrollment required while work on thesis continues. Prerequisites: BINF 5398 with a grade of “B” or better and department approval.

 

Course descriptions for other required and elective courses may be found in the Biological Sciences, Chemistry, Computer Science (CS and MIT), and Mathematical Sciences departmental listings of this Graduate Catalog.